Multiple categories of polycyclic aromatic hydrocarbons in atmospheric PM2.5 associated with changes in lipid profiles: A longitudinal study in Beijing

Lipid disorder has been demonstrated to be a key biomarker for many chronic diseases, and PM 2.5 is emerging as risk factor altered lipid profiles. However, few studies have focused on changes in comprehensive indices caused by -bound polycyclic aromatic hydrocarbon (PAH) exposure the older adult population. The aim of this study was investigate relationship between multiple categories PAHs This longitudinal including 98 adults conducted Beijing, China, from November 2016 January 2018. were analyzed using gas chromatography-mass spectrometry ion monitoring mode. Multiple classified low-molecular-weight (LMW-PAHs), high-molecular-weight (HMW-PAHs), carcinogenic (c-PAHs) noncarcinogenic (nc-PAHs) based their molecular weights carcinogenicity potentials. Linear mixed-effects models used explore association profiles, single-pollutant, two-pollutant, constituent-residual models. High-density lipoprotein cholesterol (HDL-C) levels significantly decreased 1.00% (95% CI, −1.98% −0.30%) 9.52% −13.93% −4.88%) with 10-ng/m 3 increase moving averages PAHs. In addition, significant increases total (TG), castelli I II (CRI-I II), atherogenic coefficient (AC) index plasma (AIP) 2.02% 0.10%–5.13%) 40.49% 13.88%–73.33%) found, associated Our findings suggest that may disturb proatherogenic Further are needed potential mechanism which metabolism. • first evaluating effects HDL-C levels. increased TG, Castelli indexes coefficient.